Submission Tilte

Molecular Frontiers in Cancer Genetics, Telomere Biology, and Telomere-Linked Genetic Disorders

Submission Abstract

Telomeres and telomerase, the end part of the chromosome, lie at the nexus of chromosome stability, cellular aging, and malignant transformation, making them integral domain to both fundamental biology and translational medicine. Telomere dysregulation is implicated across a spectrum of human genetic disorders — from rare telomere biology disorders to common cancers — highlighting the shared molecular mechanisms that drive genomic instability, disease onset, and progression. Advances in GWAS, functional genomics, and predictive computational models are reshaping how we understand telomere dynamics, genetic predisposition to disease, and therapeutic strategies targeting telomerase and underlying pathways. This thematic issue aims to bring together cutting-edge research that elucidates the genetic architecture and molecular mechanisms of telomere dysfunction in human disease, explores innovative therapeutic avenues, and highlights predictive biomarkers for disease risk and progression. By integrating insights from cancer genetics, telomere biology, and human genetic disorders, we seek to propel discovery that bridges basic science and clinical impact and personalized medicine.